Bern: Androgen content of testis and adrenal of white leghorn cockerels. 55, 341–349 (1943).Īrai, Y.: Effects of adrenocorticoid on response of reproductive accessories to androgen in castrated male rats. Patterson: A case of adrenal carcinoma and its hormone diagnosis. Changes in the adrenal gland of the female rat associated with the oestrous cycle.

Kennedy: Studies on the physiology of reproduction. C.: Effects of cortisone on the morphology of the mouse adrenal with special reference to changes in the X zone. 38, 122–186 (1942/43).Īlbright, F.: The effect of hormones on osteogenesis in man. J.: The possible role of the adrenal cortex in fluid shifts in the hamster following renal damage. This process is experimental and the keywords may be updated as the learning algorithm improves.Īgate, F. These keywords were added by machine and not by the authors. In this chapter, we shall summarize the evidence regarding the nature and amount of sex hormones secreted by the adrenal cortex, with primary emphasis on physiological rather than malignant states.

In this view, the biochemical behavior of malignancies need not involve the presence of “embryonic cell rests” of another tissue, or the de novo formation of new enzymes, but simply an abnormally high concentration of certain enzymes normally present in small amounts. Thus, the concept is emerging that these tissues have, to a great degree, the same set of biosynthetic enzymes, but differ in the relative activities or amounts of different individual enzymes. Present developments of enzyme chemistry point toward a qualitative similarity of the biosynthetic systems in all tissues forming steroid hormones ( Samuels 1958). The embryological origin of these tissues from adjacent portions of the dorsal mesentery provided a plausible background for similarities ( Poll 1900, Politzer 1937, Gruenwald 1942). The production of sex hormones by congenital hyperplasias or malignancies of the adrenal cortex has long been recognized as suggestive of a biochemical relationship between the adrenal cortex and the gonads.

Adrenal gland secretes